This Article was sent to me from Dr. Marcia Dawson DVM, the STCA Health Trust Chair.
Exciting news from the lab of Dr. Matthew Breen at NC State! NEW URINE TEST FOR THE DETECTION OF TCC…
Dr. Matthew Breen of NC State has developed a new urine test for the detection of bladder cancer (TCC) in dogs, and this test will soon be available to Scottie owners everywhere. Dr. Breen’s CADET test works by detecting the presence of a specific mutation in a gene called the BRAF gene. This mutation is present in 85% of the cases of canine TCC, which gives this test a very high sensitivity rating. This mutation is not present in the urine of healthy dogs or dogs that have noncancerous polyps or infection, so there is no confusion about test results. By collecting a free catch urine sample and sending this sample to Dr. Breen’s lab, we will be able to test our dogs and have results back within a couple of weeks. Furthermore, this test will pick up the presence of the mutation many months before there are any signs or symptoms of TCC in our Scotties. This super early diagnosis will allow for much earlier interventional therapies, allowing for a greater chance of making a difference in the course of the disease.
The new CADET test will be available for purchase by a year subscription plan, which will include 3 tests to be returned to Dr. Breen’s lab every 4 months, with overnight shipping included in the cost. The particulars such as how to order and the cost of the subscription will be announced soon.
So stay tuned to www.stca.biz for more info and be sure to share this announcement with your veterinarian!
Marcia Dawson DVM
The miracle of Dr. Breen’s CADET^SM BRAF test is that it can detect the presence of the mutation in remarkably few cells shed in urine, long before there are any symptoms of TCC/UC, before blood is noticed in urine, before the straining to urinate and frequency of urination, and even in some cases, before an abnormality can be seen on ultrasound. In short, this new CADET^SM test offers the gift of time.

The CADET^SM BRAF Mutation Detection Assay is now available at a substantial discount on AKC.org for AKC registrants. The test is available as an annual screener subscription package, allowing owners to proactively test their dogs on a regular basis. The service pack includes three tests, one to be carried out every four months, instructions, urine pots for sample collection, and prepaid FedEx shipping labels to send samples directly to the testing laboratory.

For breeders, Sentinel Biomedical and the AKC offer a bulk pricing so that breeders can screen all their dogs at once for a reduced rate. Once the testing laboratory receives samples, owners and breeders will receive results within two weeks.

THE FULL ARTICLE MAY BE SEEN ON THE   AKC WEBSITE–   SEARCH BLADDER CANCER ARTICLE BY Dr. Marcia Dawson, DVMBettyB